Our current research focuses on mode of action of insecticides; mechanisms of insecticide resistance; and the molecular biology, neurophysiology and neuropharmacology of two families of voltage-gated ion channels: 1) the Para family of voltage-gated sodium channels and 2) the DSC1 family of voltage-gated cation channels. While the Para family of voltage-gated sodium channels are well-known targets of insecticides, including pyrethroids, the DSC1 family of voltage-gated cation channels are potential targets of new insecticides.
Experimental models: Drosophila melanogaster; cockroaches, mosquitoes, mites and ticks.
Experimental approaches: molecular biology, electrophysiological analysis using Xenopus oocytes; Drosophila molecular genetics, neurophysiological and behavioral analysis.
438 Giltner Hall
Natural Science Building 243
288 Farm Lane
East Lansing, MI 48824